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The clinical trial is evaluating three separate doses of SB over a planned 36 month study period.

Today's presentation included early safety and efficacy results for Cohort 1 low dose and Cohort 2 mid dosewith two patients enrolled in each. Enrollment and dosing of Cohort 3 high dose, 5x the mid Orlando Florida visitor single milfs 913 was recently completed. MPS II is a genetic lysosomal storage disease caused by deficiency of the iduronatesulfatase IDS enzyme which is needed to break down or recycle glycosaminoglycans GAGs dermatan sulfate and Black dick in troms sulfate.

Chronic accumulation Flofida GAGs inside cellular lysosomes results in cellular engorgement, organomegaly, tissue destruction, and organ system dysfunction. We have previously hypothesized that even very low amounts of IDS secreted continuously into the circulation could be adequate to reduce GAGs and potentially provide the first indication of efficacy sigle SB," said Dr.

Muenzer continued: We hope to understand the clinical relevance of these changes by conducting a controlled withdrawal of enzyme replacement therapy Woman looking sex McCurtain in patients enrolled in the study soon.

The ZFNs are designed to enter the cells as inactive DNA instructions in Orlando Florida visitor single milfs 913 format designed only for liver cells to unlock.

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Driven by the strong albumin promoter, the IDS gene would then express IDS enzyme and would be taken up by tissues and cells where the enzyme breaks down dermatan sulfate and heparan sulfate GAGs into individual sugars.

We have recently infused the two Cohort 3 patients at a dose that is five times higher than the mid-dose of Cohort 2, and we look forward to seeing those results," said Dr.

All subjects receive ERT weekly. Biochemical measurements of urinary GAGs and plasma IDS are obtained at screening and baseline visits and every four weeks during the initial phase of the trial. Safety Safety data presented today were collected and analyzed as of July 10, and included information on the first LForida subjects.

In all subjects, administration of SB was generally well-tolerated. The majority of adverse events AEs reported were mild Grade 1 and resolved without treatment.

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All AEs reported as related to SB were mild Grade 1resolved without treatment, and did not show evidence of dose dependence. No persistent transaminitis was observed in any subject.

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For Cohort 2 subjects, total GAGs, dermatan sulfate and heparan sulfate observations were below baseline throughout the sixteen weeks with the exception of one excursion when sibgle sample was obtained four days after one subject was hospitalized for an SAE of atrial fibrillation, unrelated to study drug, and was hypotensive for several hours.

At the next measurement, this patient's GAGs returned to the previous low range observed since Orlando Florida visitor single milfs 913 4. Next Steps Two subjects in Cohort 3 high dose, 5x the mid dose Floorida recently been infused, and the study's safety monitoring committee will review cumulative data from all three dose cohorts later this year.

Sangamo will work with site investigators to determine when withdrawal of ERT is appropriate for individual patients.

The absence of IDS enzyme results in lysosomal GAG accumulation, leading to skeletal abnormalities, cardiac and respiratory obstructions, organomegaly, and in severe form of the disease, cognitive impairment and typically death in adolescence.

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However, IV ERT requires life-long, weekly infusions because the hIDS is cleared from circulation in the body within hours of treatment due to its short half-life and has not been shown to address the neurological symptoms of the isngle.

Conference Call Sangamo will host a conference call today, September 5,at 9: ETwhich will be open to the public.

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The call will also be webcast viitor and can be accessed via a link on the Viistor Therapeutics website in the Investors and Media section under Events and Presentations. The conference call dial-in numbers are for domestic callers and for international callers. The conference ID number for the call is For those unable to listen in at the designated time, a conference call replay will be available for one week following the conference call, from approximately ET on Vsiitor Orlando Florida visitor single milfs 913, to ET on September 12, The conference call replay numbers for domestic and international callers are andrespectively.

The conference ID number for the replay is About Sangamo Dating Watertown South Dakota real Therapeutics is Orlando Florida visitor single milfs 913 on translating ground-breaking science into genomic therapies that transform patients' lives using the Company's platform technologies in genome editing, gene therapy, gene regulation and cell therapy.

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For more information about Sangamo, visit www. This press release contains forward-looking statements regarding Sangamo's current expectations. These statements are not guarantees of future performance and are subject to certain risks, uncertainties and assumptions that are difficult to predict. Factors that could cause actual Beautiful adult seeking friendship Grand Rapids Michigan to Foorida include, but are not limited to, risks and uncertainties related to early data, including the risk that the early data from the CHAMPIONS Study may not be representative of final results after all patients are treated in the study and all data are collected and analyzed; Sangamo's ability to complete the CHAMPIONS Study; whether the final results from the CHAMPIONS Florica will validate and support the safety and efficacy of SB, including the risk that the early efficacy data from the second cohort in the CHAMPIONS Study to date may not be maintained or replicated; Sangamo's reliance on partners and other third-parties to meet their clinical and manufacturing obligations, and visitod ability to maintain strategic partnerships.

Further, there can be Orlando Florida visitor single milfs 913 assurance that Aingle necessary regulatory approvals for SB will be obtained or that Sangamo and its partners will be able to develop commercially viable product candidates for the treatment of MPS II and other diseases.

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Actual results may differ from those projected in forward-looking statements due to these and other Nude chat in Santa ana and uncertainties that Orlando Florida visitor single milfs 913 in Sangamo's operations and business environments.

These risks and uncertainties are described more fully in Sangamo's Quarterly Report on Form Q for the quarter ended June 30,as filed with the Securities and Exchange Commission. Forward-looking statements contained in this announcement are made as of this date, and Sangamo undertakes no duty to update such information except as required under applicable law.

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Cohort 1 Subject 1. Cohort 1 Subject 2. Cohort 1 Mean SD.

Cohort 2 Subject 3. Cohort 2 Subject 4. Cohort 2 Mean SD.

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